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梁宏 

点击数:7657 来源:雅博在线平台 作者: 录入:人员机构 更新时间:2021-05-18

梁宏 [教授]

联系方式

办公电话:(0773)2535678或3560088

电子邮箱:hliang@mailbox.gxnu.edu.cn


简介

梁宏,博士,教授。现任广西自治区科协副主席,省部共建药用资源化学与药物分子工程国家重点实验室/教育部重点实验室主任,广西师范大学博士生导师;曾任广西师范大学校长(2002-2017),兼任南开大学、南京大学无机化学博士生导师和中南大学应用化学博士生导师(2001-2013)。在Nat. Commun.,Coord. Chem. Rev.,J. Med. Chem.,Angew Chem Int Ed,Small,Chem. Sci.,Chem. Commun.,Eur. J. Med. Chem.,Mol. Pharm.,Chem. J,Anal. Chem.,Inorg. Chem.,CCS Chem.和《中国科学》等国内外SCI期刊发表论文400余篇,并被SCI引用8600余次;获授权国家发明专利50余项;获得广西科学技术奖特别贡献奖、广西科技进步一等奖和广西自然科学一等奖等省级科技成果奖12项。



主要研究方向

1、中药活性成分金属抗肿瘤药物化学生物学

2、新型抗肿瘤金属药物和蛋白质载药体系

 1)细胞迁移机制

 2)基于DNA和蛋白质设计新型抗肿瘤金属药物

 3)蛋白质纳米载药体系

3、诊疗一体化纳米生物材料

4、生命过程实时原位监测新方法

  

主要社会任职

英国皇家化学会会士(FRSC)

中国化学会理事

中国化学会无机化学学科委员会委员

中国化学会化学生物学专业委员会委员

广西化学化工学会荣誉理事长

国际期刊《Journal of Inorgnic Biochemistry》编委

国际期刊《Journal of NaturalMedicines Research》编委

国际期刊《Curr Pharm Des》 客座主编

中国化学会期刊《无机化学学报》编委

中国化学会期刊《化学教育》编委 

 

讲授课程

生物无机化学

 

 

近10年来主要代表性论文: 


1. Yi Gou, Guo-Jin Huang, Jin-Long Li, Feng Yang*,Hong Liang*. Versatile delivery systems for non-platinummetal-based anticancer therapeutic agents, Coordination Chemistry Reviews, 2021, 441, 213975.

 

2. Ji-Ping Yue#, Yao Zhang#, Wen-Guang G. Liang, Xue-Wen Gou, Philbert Lee, Han Liu,Wan-Qing Lyu, Wei-Jen Tang, Shao-Yu Chen, Feng Yang*, Hong Liang*, Xiao-Yang Wu*. In vivo epidermal migration requiresfocal adhesion targeting of ACF7. Nature Communications, 2016, 7, 11692

 

3. Yan-Lei Ma#, Ji-Ping Yue#, Yao Zhang#, Chen-Zhang Shi#, Matt Odenwald, WenguangG. Liang, QingWei, AjayGoel, Xue-WenGou, JamieZhang, Shao-YuChen, Wei-Jen Tang, JerroldR. Turner, FengYang*, HongLiang*, Huan-Long Qin*, Xiao-Yang Wu*. ACF7 regulates inflammatory colitis and intestinal woundresponse by orchestrating tight junction dynamics.NatureCommunications, 2017, 8, 15375

 

4. Zhen-Feng Chen*, Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li, TingMeng, Guo-Hai Zhang, Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition oftelomerase activity, and tumor cell apoptosis by organoplatinum(II) complexeswith oxoisoaporphine Journal of Medicinal Chemistry, 2015,58, 2159-2179

 

5. Zhen-Feng Chen*, Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*. Water-solubleruthenium(II) complexes with chiral 4-(2,3-Dihydroxypropyl)-formamideoxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilizationof G-quadruplex DNA, inhibition of telomerase activity, and induction of tumorcell apoptosis. Journal of Medicinal Chemistry, 2015,58, 4771-4789.

 

6. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-Wen Feng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu, Hong Liang*.Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline InduceER-Stress-Mediated Apoptosis   andPro-Death Autophagy in A549 Cancer Cells.Journalof Medicinal Chemistry, 2018, 61, 3478-3490.

 

7. Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang*, Zhen-Feng Chen*. Discoveryof a Copper-based Mcl‑1 inhibitor as an effectiveantitumor agent. Journal of Medicinal Chemistry, 2020, 63, 9154-9167.

 

8. Noor Shad Gul, Taj-Malook Khan, Yan-Cheng Liu,Muhammad Iqbal Choudhary, Zhen-Feng Chen*, HongLiang*. Pd(II) and Rh(III) complexes with isoquinoline derivatives inducedmitochondria-mediated apoptotic and autophagic cell death in HepG2 cells. CCSChemistry, 2020, 2,1626–1641.

 

9. Ke-Bin Huang, Feng-Yang Wang, Hai-Wen Feng, He-Jiang Luo, Yan Long,Tao-Tao Zou*, Albert S.C.Chan, Rong Liu, Hua-Hong Zou, Zhen-Feng Chen*,Yan-Cheng Liu, You-Nian Liu, Hong Liang*. An aminophosphonate esterligand-containing platinum(II) complex induces potent immunogenic cell death invitro and elicits effffective anti-tumour immune responses in vivo.Chemical Communications, 2019,55, 13066-13069.

 

10. Zhen-Lei Zhang, Ping Yu, Yi Gou, Ju-Zheng Zhang, Shan-HeLi,Mei-Ling Cai, Hong-Bin Sun, Feng Yang*, Hong Liang*. Novel brain-tumor-inhibitingcopper(II) compound based on a human serum albumin(HSA)-cell penetratingpeptide conjugate. Journal of Medicinal Chemistry,2019, 62, 13066-13069.

 

11. Ju-Zheng Zhang, Zhen-Lei Zhang, Ming Jiang, Shan-He Li, Hao-Liang Yuan, Hong-Bin Sun,Feng Yang*, Hong Liang*. Developinga novel Gold(III) agent to treat glioma based on the unique properties ofapoferritin nanoparticles: Inducing lethal autophagy and apoptosis. Journal of Medicinal Chemistry,2020, 63, 13695-13708.

 

12. Feng-Yang Wang, Ke-Bin Huang*, Hai-Wen Feng,Zhen-Feng Chenb You-Nian Liu*, Hong Liang* NewPlatinum (II) agent induces bimodal death of apoptosis and autophagy againstA549 cancer cell. Free Radical Biology and Medicine, 2018, 129, 418-429.

 

13. Bang-Ping Jiang, Li Zhang, Xiao-Lu Guo, Xing-Can Shen*, Yan Wang, Yang Zhu,Hong Liang*.Poly(N-phenylglycine)-BasedNanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/PhotodynamicTherapeutic Agents for Malignant Melanoma. Small, 2017, 1602496.

 

14. Yuan-Yuan Wang, Wen-Long Wang, Xing-Can Shen*, Bo Zhou, Ting Chen, Zheng-Xi Guo,Chang-Chun Wen, Bang-Ping Jiang*, HongLiang*. Combination-responsive MoO3−x-hybridized hyaluronic acid hollownanospheres for cancer phototheranostics.ACS Applied Materials & Interfaces,2018,10, 42088-42101.

 

15. Jia-Yao Xu, Ming Shi, Wen-Ting Chen, Yong Huang*, Lina Fang, Li-Fang Yao, Shu-Lin Zhao*,Zhen-Feng Chen, Hong Liang*. A gold nanoparticle-basedfour-color proximity immunoassay for one-step, multiplexed detection of proteinbiomarkers using ribonuclease H signal amplification. Chemical Communications, 2018, 54, 2719-2722.

 

16. Jia-Yao Xu, Lina Fang, Ming Shi, Yong Huang*, Li-Fang Yao, Shu-LinZhao*, Liang-Liang Zhang, Hong Liang*.A peptide-based four-color fluorescent polydopamine nanoprobe for multiplexedsensing and imaging of proteases in living cells. Chemical Communications, 2019, 55, 1651-1654.

 

17. Li-Fang Yao, Jiao-Yao Xu, Ming Shi, Yong Huang*, Li-Na Fang, Shu-Lin Zhao*,Zhen-Feng Chen, Hong Liang*.Polydopamine nanoparticle- based multicolor proximity immunoassays forultrasensitive,multiplexed analysis of proteins using isothermal quadraticamplifification. Sensors and Actuators B: Chemical. 2019, 282,626-635.

 

18. Ming-Yue Xue,Jing-Jin Zhao, Zhi-Hua Zhan, Shu-Lin Zhao*, Chuan-Qing Lan, Fang-Gui Ye, Hong Liang*. Dual functionalizednatural biomass carbon dots from lychee exocarp for cancer cell targetablenear-infrared fluorescence imaging and photodynamic therapy. Nanoscale, 2018, 10, 18124-18130.

  

部分综述:

1. Designing pro-drugs based on special residues of humanserum albumin. Curr Top Med Chem. 2016, 16: 996-1008. (医学SCI 2区)

2. Alkaloid-metal based anticancer agents. CurrTop Med Chem, 2013, 13: 2104-2115.

3. Evaluation of interactions betweenplatinum-/ruthenium-based anticancer agents and human serum albumin:Development of HSA carrier for metal-based drugs. Curr PharmDesign. 2015, 21: 1848-61. (医学SCI 2区)

  

专题评论 (EditorialArticle): 

1. HSA-basedanti-inflammatory therapy: a new and improved approach. Future MedChem. 2014, 6: 119-21. (医学SCI 2区)

2. HSA IIA subdomain-based developing anticancer metalpro-drug: a new and improved approach. Future Med Chem.2016, 8: 89-91.

3. HSA-based drug development and drug delivery systems. CurrPharm Design. 2016, 21: 1784. (医学SCI 2区)

    

2015年以来主要科研项目

(1)广西院士后备入选培养工程项目:中药活性成分无机药物及其载运体系研究(1500万元) (2017.10-2022.10)

(2)广西自治区重点研发计划项目:小龙虾细菌性疾病防治的广西中草药开发与关键技术研究(182万元)(2021.1-2023.12)

(3)国家自然科学基金-重点项目(21431001): 基于中药活性成分金属抗肿瘤配合物研究(360万元) (2015.1-2019.12)

(4)973计划专项课题:基于中药活性成分金属抗肿瘤配合物研究和天然环肽类潜药的化学组装与活性评价(255万元)(2012-2015)

(5)教育部创新团队(学术带头人,排名第二):天然活性物质的发现、结构改造与功能(450万元,2013-2016)(300万元,2017-2019滚动)

(6)国家自然科学基金(21171043): 抗肿瘤先导植物药、金属基药物与人血清白蛋白相互作用研究(80万元) (2012.1-2015.12)

   

主要荣誉称号 

国家“万人计划”(百千万工程)领军人才(2016年)

广西院士后备人选培养工程首批人选(2016年)

中国科协“西部开发突出贡献奖”(2008年)

全国优秀科技工作者(2005年)

教育部第三届“高校青年教师奖”(2002年)

中国青年科技奖(2001年)

国家有突出贡献的中青年专家(1999年)

广西优秀专业技术人员(1999年)

“广西十百千人才工程”第一层次人选(1998年)

国家“百千万人才工程”首批人选(1996年)

国务院政府特殊津贴(1996年)

广西优秀专家(1996年)